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Breast Cancer

Bringing you comprehensive information about different types of breast cancer

Breast Cancer

Bringing you comprehensive information about different types of breast cancer

AOI > Cancer Types > Breast cancer > Treatments

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    Treatment

    Treatment options for breast cancer include surgery, chemotherapy, hormone therapy and radiotherapy. A combination of two or more of those treatments is often used. The treatment modalities used depend on: the cancer itself-its size and stage (whether it has spread), the grade of the cancer cells and whether it is receptive to hormones or contains HER2 receptors. Alongside, causes and risk factors are also taken into consideration before suggesting the treatment option for breast cancer.
    Surgeries used to treat breast cancer include:

    • Removing the breast cancer (lumpectomy)
    • Removing the entire breast (mastectomy)
    • Removing a limited number of lymph nodes (sentinel node biopsy)
    • Removing several lymph nodes (axillary lymph node dissection)
    • Removing both breasts

    What are the different types of treatments for breast cancer?

    Surgical Treatment of Breast Cancer

    There are two main types of surgery to remove breast cancer:
    What is lumpectomy vs. mastectomy?

    Breast-conserving surgery (BCS) also referred to as a lumpectomy, partial mastectomy or segmental mastectomy, quadrantectomy, is procedure which is performed to remove the part of the breast containing the cancer. This surgery is done to remove the cancer and some of the normal tissue around it. The amount of breast removed depends on where the tumor is and how large it is, and on other factors.

    Mastectomy is a surgery to remove the entire breast including all of the breast tissue and sometimes other tissues in the vicinity. There are various forms of mastectomy. Some of the women can also have double mastectomy, in which both the breasts are removed.

    Why choose lumpectomy or mastectomy?
    Most women with early-stage cancers have the option to choose between BCS and mastectomy. The significant advantage of BCS is that a woman can have most of her breast as only the part of the tissue with cancer cells will be removed, yet she still needs radiation in most cases. Women who undergo mastectomy are less likely to get chemotherapy for early stage cancers.

    Mastectomy could be a better and safer option for many women because of the breast cancer type, tumor size, prior radiation treatment, or other factors. Many women may be concerned about the possibility of cancer recurrence from a less extensive surgery. Over the past 20 years, studies show that the survival rate for the people having BCS with radiation is equivalent to undergo mastectomy.

    Surgery to Remove Nearby Lymph Nodes

    To assess the spread of breast cancer to axillary lymph nodes, one or more of these lymph nodes will be removed and observed in the laboratory. This is an important aspect to find out the cancer stage. Lymph nodes can either be removed as part of breast cancer surgery or as a separate operation.

    What is a lymph node biopsy and what is a sentinel node biopsy?

    There are two main types of surgery to remove lymph nodes including:

    Sentinel lymph node biopsy (SLNB): In this procedure, the surgeon removes only the lymph nodes under the arm where the cancer will possibly spread first. Removing only one or more lymph nodes decreases the risk of surgical side-effects such as swelling of the arm, also known as lymphedema.

    Axillary lymph node dissection (ALND): In this procedure, the surgeon removes many axillary lymph nodes (usually less than 20). ALND is not used much, but it can still be the best way to remove the lymph nodes in some situations.

    What is breast reconstruction surgery?

    Many women who have breast cancer surgery can have the option of breast reconstruction. A woman having mastectomy prefers have the breast mound rebuilt after surgery to restore the appearance of the breast. A woman may consider in getting fat grafted into the affected breast in certain breast-conserving procedures to remove any dimples left from the surgery. The option of breast reconstruction depends on the medical situation and personal preferences of the woman. The patient can opt for breast reconstruction at the same time as the surgery (immediate reconstruction) or later (delayed reconstruction).

    Patients may undergo breast reconstruction surgery at the same time or after mastectomy. A plastic surgeon with special training in reconstruction surgery performs this kind of procedure. The surgeon uses an implant or tissue from another any part of the body to create a breast-like shape that substitutes for the missing breast. The surgeon may even make a nipple outline and add a tattoo, which looks like the areola (the dark region around the nipple).

    There are two main types of breast reconstruction surgery:

    Breast implant: Breast reconstruction with an implant is performed in steps such as:

    • The plastic surgeon places a balloon expander under the chest muscle which is the first step in the procedure, also called as tissue expansion.
    • Saline is applied to the expander over weeks or months to stretch the chest muscle and the skin above it. This phase creates an implant pocket.
    • When the pocket is the appropriate size, the surgeon removes the expander and inserts an implant in the pocket (filled with saline or silicone gel). This creates a new breast-like shape.
    • Although it looks like a breast, since nerves were cut during the mastectomy, you will not have the same feeling as before.

    Breast implants do not last a lifetime. If you want to have an implant, you will possibly need further surgery to remove it or repair it later on. Implants can cause issues such as breast hardness, pain and infection. An implant can break, move or change its position too. These problems can occur soon after the surgery in in later times.

    Tissue flap: A reconstructive plastic surgeon with special training performs this surgery. He creates a new breast-like shape from the muscle, fat, and skin taken from other parts of the body (usually the belly or back) in tissue flap surgery. This new shape to the breast should last for lifetime. Women who are extremely underweight or obese, who smoke or who have severe health issues cannot undergo tissue flap surgery. Healing after this surgery sometimes takes longer than healing after surgery with the breast implant. You may have other issues, such as infection, low wound healing capacity and pain.

    What is recovery like after breast cancer surgery?
    Any patient who undergo breast cancer surgery can expect few after effects including:

    • To be taken to a recovery room where blood pressure, pulse and breathing of the patient are monitored
    • Can experience possible pain, numbness and a pinching sensation in the axillary area

    It is important for a patient to follow certain set of measures to avoid any complications after the surgery. Doctor should give instructions to the patient on:

    • How to care of themselves at home, including taking care of the incision and drains, identifying the signs of infection, and understanding activity restrictions
    • When to resume wearing a bra or wearing a breast prosthesis
    • Prescriptions for pain medication and antibiotics
    • Instructions on regular diet and daily routine

    Patients who have breast reconstruction after mastectomy are advised to spend one night in the hospital. Those undergoing mastectomy without reconstruction or lumpectomy may leave the hospital the day of surgery with the proper instructions and guidance from the doctor for home care.

    Radiation Therapy (RT) After Surgery

    Many women who undergo a lumpectomy may have radiation treatment to the breast following surgery, and sometimes the underarm area. Likewise, some of the women who are under the treatment of mastectomy can have radiation therapy to chest along with the underarm area. Radiation therapy is given after the chemotherapy if the treatment plan includes chemotherapy.

    Radiation Therapy

    What are the different types of radiation therapy?
    High-powered energy beans such as X-rays and protons through external beam (a large machine that targets body’s energy beams) or brachytherapy (inserting radioactive material within the body) are used in radiation therapy to destroy cancer cells.

    After the lumpectomy, external beam radiation of the whole breast is commonly used. If you are at low risk of cancer recurrence, breast brachytherapy may be an option after lumpectomy. Doctors may also advise the treatment of chest-wall radiation following mastectomy for larger breast cancer or lymph node propagation cancer. Based on the course of treatment, breast cancer radiation may last from three to six weeks. Depending on the condition, cancer type and tumor position, the radiation oncologist decides which treatment is best for the patient.

    Side effects of radiation therapy include:

    • Fatigue
    • Swollen breast tissue or it may appear more firm
    • Red sunburn-like rash where the radiation is aimed
    • Damage to the heart or lungs, second cancers in the treated area

    Chemotherapy

    What is chemotherapy treatment for breast cancer?

    Chemotherapy can be used as the primary or sole treatment for cancer. It can be used to kill any cancer cells that remain in the body after other treatments which is called as adjuvant therapy. Neoadjuvant therapy is the chemotherapy that can be used to shrink a tumor before surgery or radiation therapy. Palliative Chemotherapy is used to relieve signs and symptoms of cancer by killing some of the cancer cells. It is also used to relieve cancer symptoms especially pain.

    Should I have chemotherapy before breast cancer surgery?

    Chemotherapy is used to destroy cancer cells by using anti-cancer or cytotoxic medications. It is often used in women with large breast tumors before surgery with the aim of reducing tumor size making it easier to remove with surgery. If your cancer has a high risk of returning or spreading to another part of the body after surgery, your doctor may recommend chemotherapy to decrease the chance of the cancer recurrence.

    Side effects of chemotherapy depend on the medications you receive. Common side effects include:

    • Fatigue
    • Hair loss
    • Increased risk of developing infection
    • Vomiting
    • Nausea

    Rare side effects include:

    • Blood cell cancer
    • Premature menopause
    • Damage to the heart and kidneys
    • Infertility (if premenopausal)
    • Nerve damage

    Hormone Therapy

    What is hormone therapy treatment for breast cancer?

    Hormone therapy, most probably referred to as hormone-blocking therapy is used to treat breast cancers that are sensitive to hormones. Such cancers are referred to as positive estrogen receptor (ER positive) and positive progesterone receptor (PR positive) cancers by physicians. Hormone therapy may be used before or after surgery or other treatments to reduce the risk of returning of cancer. Hormone therapy can shrink and control if the cancer has spread already.

    Treatments that can be used in hormone therapy include:

    • Medications that stop the body from producing estrogen after menopause (aromatase inhibitors)
    • Medications that block hormones from attaching to cancer cells (selective estrogen receptor modulators)
    • Surgery or medications to stop hormone production in the ovaries

    Side effects of hormone therapy depend on the specific treatment, but may include:

    • Night sweats
    • Vaginal dryness
    • Hot flashes
    • More serious side effects include a risk of bone thinning and blood clots

    Targeted therapy

    Targeted therapy is a treatment modality of cancer that uses medications and is completely different from traditional chemotherapy. Several medications used in targeted therapy medicines focus on a protein called human epidermal growth factor receptor 2 (HER2) that is overproduced by certain breast cancer cells. This protein helps in the development and growth of breast cancer cells. These medications can kill cancer cells while protecting healthy cells by targeting cells that produce too much HER2. This modality helps to stop cancer cells from developing and prevent from spreading into other organs.

    There are targeted therapy medicines available that focus on other abnormalities within the cancer cells. You may be advised to get your cancer cells tested to see if you could benefit from targeted therapy medications. After surgery some medicines are used to reduce the risk of the cancer recurrence. Others are used to slow the tumor growth in advanced cases of breast cancer.

    Immunotherapy

    What is immuno therapy treatment for breast cancer?

    Immunotherapy for the treatment of breast cancer is the process by which the immune cells are activated to fight cancer cells. It is a personalized treatment aimed at enhancing the body’s defence mechanism to fight and destroy cancer cells. Immunotherapy uses the patient’s own body cells to boost or restore the function and strengthen the immune system to combat breast cancer. Some of the cancer cells produce proteins that mimic the cells of immune system by which the disease-fighting immune system of your body may not attack the cancer cells. The medications used in immunotherapy interfere with this mechanism aiding to kill cancerous cells.

    If you have triple-negative breast cancer, immunotherapy may be an option, which means the cancer cells do not have receptors for estrogen, progesterone or HER2. Immunotherapy is combined with chemotherapy for triple-negative breast cancer, to treat advanced cancer that is spread to other parts of the body.

    Palliative Care

    Palliative care is the specialized medical care that focuses in providing pain relief and other symptoms of serious diseases. Palliative care specialists are working with you, your family and your other physicians to provide an extra support that complements your ongoing care. It can be used in other treatments modalities such as surgery, chemotherapy or radiation therapy. Patients with cancer may feel better and live longer when palliative care is used in conjugation with other treatment methods. A team of doctors, nurses and other specially trained professionals perform palliative care. These health care teams are aimed at improving the quality of life for cancer patients and their families.

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