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Uterine Cancer

Bringing you comprehensive information about different types of Uterine Cancer

Uterine Cancer

Bringing you comprehensive information about different types of Uterine Cancer

AOI > Cancer Types > Uterine Cancer > Treatment

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    What are the different types of treatments for uterine cancer?

    The treatment for uterine cancer depends on your diagnostic results which may include biopsies and imaging scans, as well as blood tests.

    Besides, the treatment also depends on other factors such as your medical records, general health history, the type and stage of cancer, as well as your individual fertility concerns, etc.

    Our surgeons at AOI may perform a variety of uterine treatments, that includes:

    • Surgery
    • Radiation Therapy
    • Chemotherapy
    • Immunotherapy
    • Hormone Therapy

    However, for uterine cancer, surgery is one of the main treatment options.

    Uterine Cancer Surgery

    As mentioned, surgery is the main treatment for uterine cancer. Usually, surgery for uterine cancer includes:

    • Total hysterectomy or surgical removal of the uterus
    • Bilateral salpingo-oophorectomy or removal of both ovaries and fallopian tubes
    • Biopsy of the omentum, a fat pad in the pelvis
    • Lymphadenectomy or removal of lymph nodes in the pelvis and lower abdomen

    Surgery for uterine cancer may also include:

    • Pelvic washings: After the removal of the uterus, the surgeon puts saline (salt water) into the pelvic area which is then examined under a microscope.
    • Tumor debulking: If the cancer has spread into the abdomen, the surgeon removes as much of the cancer as possible before proceeding with other types of treatment. The procedure is also called as debulking.

    Hysterectomy

    What is hysterectomy?

    Depending on the extent of the cancer, the surgeon will perform either of the two procedures:

    • Simple hysterectomy: It is removal of the uterus and cervix.
    • Radical hysterectomy: This is removal of the uterus, cervix, the upper part of the vagina, and nearby tissues.

    For women who have been through menopause, the surgeon will also perform a bilateral salpingo-oophorectomy, which is the removal of both fallopian tubes and ovaries.

    Your gynecologic surgeon may perform the hysterectomy in one of the following ways:

    • Open surgery: During this procedure a large incision is made in the abdomen to remove the organs.
    • Minimally invasive surgery using laparoscope: This procedure uses several small incisions to remove the organs. The uterus, however, is removed through the vagina.
    • Robotic-assisted surgery: During this procedure a camera and instruments are inserted through small, keyhole-sized incisions. With the help of robotic instruments, the surgeon removes the uterus, cervix, and surrounding tissue.

    If there’s no cancer remaining in the tissue during the hysterectomy, additional treatment may not be needed. However, regular screening and testing is recommended.

    Hysterectomy recovery

    Post hysterectomy, the recovery time in hospital and at home, before you can actually get back to your regular activities will vary as it depends on the procedure you had.

    Most women are discharged from the hospital within 2-3 days, after the surgery, but complete recovery usually takes a few weeks.

    During this time, patients need to rest at home and refrain from doing housework and lifting heavy objects. Walking is encouraged, though.

    After about 6 weeks, they can gradually start getting back to their regular activities.

    For most women, life without a uterus means relief from the symptoms but if the ovaries too were removed, there are a few more challenges ahead, especially if the patient had not gone through menopause before their hysterectomy. Soon after the procedure, patients probably will begin having symptoms such as hot flashes and mood swings. And, for some women, hysterectomy can get mentally taxing as they may grieve over the loss of the uterus and their ability to have children.

    For more hysterectomy recovery tips, it’s advisable to talk to the surgeon or a mental health therapist.

    Hysterectomy side effects

    After hysterectomy surgery for uterine cancer, the most common short-term side effect includes pain and tiredness. Among other side effects, the commonly experienced ones include nausea and vomiting as well as difficulty emptying the bladder and having bowel movements.

    Post surgery for uterine cancer, a woman’s diet may be limited to liquids, followed by a gradual return to solid foods.

    Besides, if the ovaries are also removed during the procedure, this will result in early menopause (if the woman has not already gone through menopause). Therefore, a woman is likely to experience menopausal symptoms, including hot flashes and vaginal dryness.

    If a lymphadenectomy or removal of lymph nodes is done, some patients may experience swelling in their legs, called lymphedema.

    After a hysterectomy, women can no longer become pregnant, so premenopausal women who wish to preserve their fertility should talk to their doctor before the treatment begins.

    Sexual and emotional side effects are common after the surgery, so women are encouraged to discuss and find ways to address these issues before and after the cancer treatment.

    The risks of uterine cancer treatment will include some short and long-term side effects, depending on the stage and grade of cancer, so it is important to discuss these with your surgeon well in advance.

    Hysterectomy procedure

    The type of hysterectomy procedure depends on your medical history and general state of health. It also depends on the extent of the cancer growth.

    Usually pelvic and para-aortic lymph nodes will also be biopsied during surgery to help find out the stage of cancer.

    That said, a hysterectomy for uterine cancer may be done with an incision in the abdomen. Sometimes robot-assisted and a laparoscopic hysterectomy is possible as well.

    Hysterectomy types

    • Abdominal hysterectomy: During this procedure, the uterus, ovaries, and fallopian tubes are removed through a large opening into the abdomen. This allows the surgeon to easily see the organs and to find out the extent of the cancer. Post abdominal hysterectomy, the usual stay in the hospital is about 3 days.
    • Laparoscopic hysterectomy: The minimally invasive surgery is done with a tiny camera and special instruments. The surgeon puts these tools through several small incisions in the abdomen.
      After the procedure, the patient may stay in the hospital for 1 or 2 days or they may be able to go home the same day.
    • Robotic hysterectomy: During this advanced procedure, the surgeon’s movements are mimicked by robotic arms that remove uterus through small incisions. Post surgery, most women come home the next day. If the cervix is removed, they will have to follow a few restrictions.

    Robotic surgery is one of the latest advancements in surgical cancer care which allows the surgeon to perform even the most complex surgeries with utmost precision.

    At American Oncology Institute (AOI), our surgeons use the da Vinci Surgical System which offers unmatched results. For patients, this means shorter recovery, fewer complications and smaller scars.

    The unmatched level of surgical expertise at AOI allows us to produce exceptional outcomes and therefore, many of our patients report a higher quality of life during recovery.

    Hysterectomy complications

    Though the hysterectomy is a safe surgery, if you experience any of these symptoms listed below, call for your surgeon immediately:

    • Fever or chills
    • Heavy bleeding or unusual vaginal discharge
    • Severe pain
    • Redness or discharge from incisions
    • Problem urinating or having a bowel movement
    • Shortness of breath

    AOI is a high-volume cancer hospital that offers surgical expertise that far exceeds other providers. Our surgeons consistently achieve successful outcomes and improved quality of life for cancer patients.

    Partial hysterectomy

    A partial hysterectomy deals with removal of a woman’s uterus, leaving her cervix intact. The procedure may be recommended to treat uterine cancer, as well as uterine fibroids, endometriosis, uterine prolapse pelvic pain or abnormal vaginal bleeding. Depending on the stage of the cancer, the size of the patient’s uterus and other individual factors, a partial hysterectomy can be performed through either of the following surgical techniques:

    • Vaginal approach – This approach is generally followed in case of early stage cancers where the surgeon is able to remove a uterus through an incision made in the vagina. This technique results in a faster recovery than an open approach and leaves no visible scarring.
    • Abdominal approach – To remove a large tumor or enlarged uterus, a surgeon may perform an open hysterectomy.
    • Laparoscopic approach – A partial hysterectomy can also be done laparoscopically, during which a surgeon creates one or more small incisions in the abdominal area, through which a tiny light, camera and specialized instruments are inserted. This allows a surgeon to view the uterus on an external video screen to facilitate its removal. The procedure can be done with or without robotic assistance.

    Total hysterectomy

    A total hysterectomy is a procedure that deals with removal of a woman’s uterus, cervix and surrounding tissue. This procedure may be recommended to treat gynecologic cancers such as uterine cancer, as well as endometriosis, fibroid tumors, abnormal vaginal bleeding and chronic pelvic pain.

    Whether a uterine cancer patient is a candidate for a total hysterectomy depends on factors, such as the type, size, location, grade and stage of the tumor, as well as general health of the patient.

    Sometimes, a total hysterectomy is performed in conjunction with other nonsurgical cancer treatments, such as chemotherapy, radiation therapy and hormone therapy. These treatments may be administered either prior to or after the surgery to help prevent cancer from growing, spreading or recurring.

    If a total hysterectomy is recommended to address uterine cancer, a surgeon might also suggest and perform a bilateral salpingo-oophorectomy, a procedure that involves removal of both ovaries and both fallopian tubes during the same surgical session.

    Two types of total hysterectomy surgery include:

    • A simple or total abdominal hysterectomy – The uterus is removed through an incision in the abdomen.
    • A vaginal hysterectomy – The uterus is removed through an incision in the vagina.

    To perform these surgeries, a surgeon may use robotic assistance, or a minimally invasive technique called laparoscopy. Both the techniques are effective and safe.
    When dealing with laparoscopic technique, a surgeon creates one or more tiny incisions through which they insert a tiny camera and specialized instruments, and then remove the uterus while viewing the surgical site on a large screen.

    Women who are confused about their ovarian cancer treatment options are welcome to consult with the gynecologic cancer experts at AOI. We take a multispecialty approach to treat cancer and provide the latest advances in cancer prevention, diagnosis, treatment and support in all our cancer hospitals.

    How is lymph node removal performed?

    Based on the stage of uterine cancer, sometimes lymph nodes in the pelvis and around the aorta are also to be removed. This is called lymph node dissection. It is usually done through the same incision as the abdominal hysterectomy but in case the hysterectomy is done vaginally, lymph nodes can be later removed with laparoscopic surgery.

    When only a few of the lymph nodes are removed, it’s called lymph node sampling.

    But again depending on the cancer type and grade, the tumor size, and how deeply the cancer invades the muscle of the uterus, and imaging test results, lymph nodes might not need to be removed at all.

    What happens if lymph nodes are removed?

    If cancer cells break away from a tumor, the first place they travel to is the nearest lymph nodes, which are a part of the lymphatic system. Thus, your surgeon removes them during the surgery so that they do no spread any further.

    Side-effects of lymph node removal

    Removing lymph nodes in the pelvis can increase the risk of vein inflammation and nerve damage. It can also lead to a build-up of fluid in the legs and genitals, called lymphedema. This can become a life-long problem and is more likely to occur if radiation is given after the surgery.

    However, if only your pelvic lymph nodes were removed, you have a smaller risk of developing lymphedema in your legs. But these risks can be avoided or minimized by using sentinel node biopsy.

    How long does lymph node removal surgery take?

    Lymph node dissection is usually done at the same time as the operation to remove the uterus. But if at all a patient is undergoing an abdominal hysterectomy, the lymph nodes can be removed through the same incision.

    Does having lymph nodes removed affect your immune system?

    Lymph nodes are part of the body’s immune system as they help fight infection by filtering harmful bacteria and cancer cells from your body. They also play a crucial role in cancer diagnosis, treatment and prognosis.

    A full clearance may have some affect but not as much as for those who are having/have had chemotherapy.

    What is bilateral salpingo-oophorectomy?

    The surgery that deals with removal of ovaries and fallopian tubes is called salpingo-oophorectomy.
    Removal of one ovary and fallopian tube is called a unilateral salpingo-oophorectomy but when both ovaries are removed, it’s called a bilateral salpingo-oophorectomy.

    The surgical procedure helps to treat a variety of conditions, including ovarian cancer. Also, it has proved to be highly effective in lowering the risk of breast and ovarian cancer in women who are at high risk.

    Is salpingo oophorectomy considered major surgery?

    In a way it is a major surgery because after your ovaries are removed, you’ll be infertile. So that’s an important consideration, especially if you’re premenopausal and would like to have children.

    What happens after bilateral salpingo oophorectomy?

    Once both your ovaries and fallopian tubes are removed, you’ll no longer have periods or be able to get pregnant. So if you still want to get pregnant, discuss all your options with your gynecologist.
    Also, because you’ll have menopause soon after the surgery, you may have certain side effects on the body.

     

    How long does bilateral salpingo oophorectomy surgery take?

    Salpingo-oophorectomy can be approached in several ways and usually it takes between 1 – 4 hours.

    • Open abdominal surgery: Traditional surgery requires general anesthesia, followed by which a surgeon makes an incision in your abdomen and removes the ovaries and fallopian tubes. Once the surgery is done, the incision is stitched, stapled or glued.
    • Laparoscopic surgery: The minimally invasive procedure, during which the surgeon makes several small incisions to access and remove the ovaries and fallopian tubes can be performed under general or local anesthesia. A laparoscope is a tube which has a light and a camera attached to it. This allows your surgeon to see your pelvic organs without making a large incision.
    • Robotic surgery: During this procedure, the surgeon makes small incisions and uses a robotic arm that allows for high-definition visualization. Precise movements of the robotic arm allow the surgeon to locate and remove the ovaries and fallopian tubes, followed by which the incisions are closed.

    What is the recovery time for a salpingo oophorectomy?

    When done laparoscopically or using robot, the surgery may require an overnight hospital stay. But it can sometimes be done on an outpatient basis as well. On the other hand, the open abdominal procedure may require a few days in the hospital.

    As part of recovery, you’ll be encouraged to walk, but you’ll also be instructed to avoid lifting weight or engage in strenuous exercise for a few weeks.

    You can expect some vaginal discharge following surgery, but that’s normal. Other than that, depending on the specifics of your surgery, your surgeon will give you specific instructions. Remember, everyone recovers at their own pace.

    When compared with open abdominal incision, laparoscopic and robotic surgeries cause less post-surgical pain and less scarring. This results in faster healing.

    What is omentectomy?

    This is the surgical procedure that deals with removal of all or part of the omentum, the layer of fatty tissue inside the abdomen that surrounds the stomach, large intestine and other abdominal organs. This tissue contains the lymph nodes, lymph vessels, nerves and blood vessels.

    There are two types of omentectomy:

    1. Supracolic omentectomy or total omentectomy: During this procedure, the entire omentum is removed.
    2. Partial omentectomy: Also called as infracolic omentectomy, during this procedure only a part of the omentum is removed.

    An omentectomy is typically performed in combination with the hysterectomy or a salpingo-oophorectomy.

    Omentectomy side effects

    Some risks and side-effects of omentectomy surgery include:

    • Damage to nearby organs
    • Infection
    • Lymphedema
    • Nausea
    • Permanent nerve damage
    • Bleeding

    Omentectomy complications

    Although an omentectomy is a relatively safe procedure, certain complications can arise in a few rare cases. These complications include:

    • Pain
    • Lymphedema – buildup of fluid caused by lymph-vessel blockage
    • Nerve damage that could be permanent

    Recovery

    Recovery from omentectomy depends on other procedures you have had. For instance, if you have had a hysterectomy or salpingo-oophorectomy during the same procedure, it could take as long as eight weeks for complete recovery.

    Peritoneal Biopsies

    What is peritoneal biopsies?

    A peritoneal biopsy is a diagnostic test that takes a sample of tissue from the peritoneum or the lining that covers the organs in the stomach to see if it contains any cancer cells.

    During a biopsy, a small piece of tissue is extracted to look at it under a microscope. Once the surgeon has taken the biopsy, they will send it to the laboratory where it will be examined by a pathologist.

    How does peritoneal biopsies work against uterine cancer?

    Peritoneum comprises of the tissue lining, the pelvis and abdomen and the peritoneal biopsies deal with removal of the small piece of this lining to check for cancer cells.

    How is peritoneal biopsies given?

    A peritoneal biopsy is commonly done in two ways:
    Laparoscopy – This procedure allows the surgeon to look at other areas in your abdomen and take more biopsies if needed. This test is done under general anesthesia. Your surgeon will make a small cut in the abdomen wall, put a thin tube with a light and camera at the end (laparoscope) into your stomach and will take a small biopsy of the peritoneum.

    CT or ultrasound guided biopsy – During this procedure, your surgeon will give you a local anesthesia to numb the area, followed by which they will use an ultrasound or a CT scan to help guide them to the right place. Then, they pass a special needle, through your skin into the area they want to take a biopsy from.

    Having a peritoneal biopsy can be uncomfortable but should not be painful.

    Tumor Debulking

    What is tumor debulking?

    It is the surgical removal of as much of a tumor as possible. Tumor debulking is advantageous as it allows chemotherapy or radiation therapy to work more effectively and kill all the tumor cells. In some patients it is to be done to relieve them of symptoms or help them live longer. It is also called debulking.

     

    How does tumor debulking work against uterine cancer?

    If uterine cancer has spread, the surgeon might try to take out as much of it as possible. This is called debulking.

    Debulking a cancer can help other treatments, like radiation or chemotherapy to work better and more effectively. So, it is helpful in treating some types of endometrial cancer.

    Also women who have more advanced disease, especially stage III or IV will often have to undergo debulking surgeries. This means that their surgeon will attempt to remove as much tumor as possible because the more tumor that is debulked, the better the long-term outcome for the patient.
    In patients with very advanced cancers, debulking may be used for palliation or easing their pain or symptoms, rather than trying to cure the disease.

    How is tumor debulking given?

    For the early stage uterine cancers, all visible cancer can be removed during the surgery itself. Unfortunately, in patients with stage IV or advance disease, the removal of all tumor cannot be achieved. Besides, treatment of stage IV uterine cancer is dictated by the site of metastatic cancer and symptoms related to the spread of cancer. Therefore, debulking surgery is often performed so that radiation therapy and/or chemotherapy will have fewer cancer cells to kill. This, however, is a major surgery and has many potential complications.

    Tumor debulking success rate

    Debulking a cancer can help other treatments, like radiation or chemotherapy to work better and more effectively. Also by applying the principles of debulking, surgery can significantly improve the outcomes of the disease as the surgery helps to relieve pain and symptoms caused by the tumor.

    What is recovery like after uterine cancer surgery?

    After uterine cancer surgery, your recovery time will depend on your age, general health and the type of surgery that you had. Most women feel better within 1–2 weeks and are able to fully return to normal activities after 4–8 weeks.

    Radiation Therapy

    What is radiation therapy?

    Radiation therapy uses high-energy x-rays or other particles to destroy abnormal cancer cells. Depending on the stage and grade of your cancer, radiation therapy regimen usually comprises of a specific number of treatment cycles. This is given over a set period of time.

    What are the different types of radiation therapy for uterine cancer?

    External Beam Radiation Therapy (EBRT): This type of radiation therapy directs an external beam of radiation at cancerous tissues inside the body. The modality of cancer treatment uses doses of radiation to destroy or shrink cancerous tumors.

    Among many other benefits, the targeted external beam radiation therapy helps to lower the side-effects that increase the risk of gastrointestinal and sexual function.
    Some additional advantages of EBRT may include:

    • Fast and painless outpatient procedure
    • No risks or complications
    • Unlike chemotherapy, ERBT is targeted to the area being treated.

    High-dose rate (HDR) brachytherapy: The internal radiation therapy delivers radiation from implants placed inside or close to the tumor in the body. Cancer often affects organs and other body parts and therefore, it is important for radiation treatment to be highly focused so as to be able to minimize its serious side effects.

    Through this technique maximum radiation dose is given to cancerous tissues while minimizing exposure to the surrounding healthy tissue.

    Intensity modulated radiation therapy (IMRT): The advanced technique uses software to plan a precise dose of radiation, based on the size, shape and location of the tumor. A computer-controlled device called a linear accelerator delivers radiation that matches the 3D geometrical shape of the tumor.

    The IMRT therapy works best for people who have previously had radiation therapy for uterine cancer and are experiencing recurrent tumors in the treated area.

    How does radiation therapy work against uterine cancer?

    Use of radiation therapy to treat uterine cancer depends on the stage and grade of the cancer. It may be used after a hysterectomy or as the main treatment when surgery is not possible. That said, radiation therapy may also be used at other stages of treatment.

    American Oncology Institute (AOI) provides the most advanced radiation treatments for uterine cancer, including:

    • Brachytherapy: Tiny radioactive seeds are placed in the body close to the tumor
    • 3D-conformal radiation therapy: Several radiation beams are given in the exact shape of the tumor
    • Intensity-modulated radiotherapy (IMRT): Treatment is tailored to the specific shape of the tumor.

    New radiation therapy techniques allow our radiation oncologists to target uterine cancer tumors more precisely, delivering the maximum amount of radiation with the least damage to healthy cells.

    How is radiation therapy given?

    Radiation therapy can be delivered externally or internally. Though the most common type of radiation treatment for uterine cancer is external-beam radiation therapy (EBRT). During this therapy, a machine outside the body delivers radiation to the pelvic region or the area marked by your radiation oncologist. But in some patients, radiation can also be delivered internally. This form of radiation is called brachytherapy. Sometimes external-beam radiation therapy can also be given in combination with brachytherapy. For some people, brachytherapy alone will be recommended.

    How often do you receive radiation therapy?

    The radiation therapy is most often given after surgery to destroy any remaining cancer cells but it may also be given before surgery to shrink the tumor. But in some cases where women cannot undergo surgery, the doctor may recommend radiation therapy instead.

    In case of uterine cancer treatment, radiation therapy may be directed towards the whole pelvis and/or applied only to the vaginal cavity, called as vaginal brachytherapy.

    In case of grade 1 or 2 cancer that has spread through half or more of the myometrium or in case of grade 3 cancer that has spread through less than half of the myometrium, women may have to undergo vaginal brachytherapy instead of radiation to the pelvis region.

    But on the other hand, for some women, radiation therapy to the pelvis may be the best option to help prevent a return of the cancer.

    A typical course of radiation for uterine cancer would entail daily radiation treatment, for 3 to 5 weeks. During radiation therapy the patient is unlikely to feel any discomfort, infact, they continue to work during the weeks of treatment.

    How can you tell if radiation therapy is working?

    There are a number of ways your healthcare team can determine if the radiation therapy is working for you. These include:

    • Imaging Tests: Tests such as CT scans, MRI scans, PET scans during or after the treatment reveal how the tumor has responded.
    • Blood Tests: Some tumors can be measured in the blood with the help of tumor marker. Tumor marker is a substance that is either made by the tumor or by the body. If the treatment is responding, the tumor marker starts to decrease.
    • Symptoms: Sometimes when the patient stops experiencing any symptoms such as pain, it could be a sign that the tumor is shrinking.

    Radiation therapy success rate

    Radiation is most often used after surgery to treat uterine cancer. The treatment has potential to kill any cancer cells that may still be left in the treated area.

    In case of metastatic uterine cancers, especially large cancers, which may respond poorly to chemotherapy, radiation therapy may enhance the chance of the cure. Even in case of recurred uterine cancers, these can be cured with radiation therapy following surgery.

    At American Oncology Institute, the best hospital for radiation therapy in India, we use a highly targeted form of radiation therapy to treat uterine cancer, along with other treatment modalities like chemotherapy and hormone therapy.

    By focusing the radiation directly on the tumor, these therapies reduce the risk of developing common radiation side effects, including issues related to gastrointestinal and sexual function.

    What are the possible side effects of radiation therapy?

    Side effects from radiation therapy usually depend on the extent of radiation therapy given. It may include minor symptoms such as fatigue, mild skin reactions, upset stomach, and loose bowel movements. Most of these side effects go away soon after the treatment is finished. Also with the use of modern machines and other state-of-the-art techniques, radiation oncologists are now able to significantly reduce these side-effects.

    What are the limitations of radiation therapy?

    Sometimes radiation therapy can also cause damage to surrounding tissues, such as lung, heart, etc., depending on how close the area of interest is located to the tumor.

    Chemotherapy

    What is chemotherapy treatment for uterine cancer?

    When recommended for uterine cancer, chemotherapy usually is given after the surgery. Chemotherapy is also considered as a treatment option if the uterine cancer returns after the person’s initial treatment.

    Basically, the goal of chemotherapy is to shrink, slow or destroy cancer cells remaining after surgery especially if it comes back or has spread to other parts of the body.

    Although chemotherapy can be given orally, most drugs used to treat uterine cancer are given intravenously (IV).

    What is chemotherapy?

    Chemotherapy is a type of cancer treatment that uses drugs (usually in combination) to destroy cancer cells. It keeps the cancer cells from growing, dividing, and making more cells.

    How does chemotherapy work against uterine cancer?

    Use of chemotherapy to treat uterine cancer is usually for late-stage cancers that have spread beyond the uterine lining to other organs and tissues or have recurred.

    At American Oncology Institute (AOI), the best hospital for chemotherapy in India, our multispecialty team of experts take a highly individualized approach to treat uterine cancers. Our team works closely with each patient and if chemotherapy is recommended, determine the most appropriate medications, dosages and treatment plans.

    Which uterine cancers are treated with chemotherapy?

    Chemotherapy is often part of the treatment plan when uterine cancer has spread beyond the endometrium to other parts of the body and surgery can’t be done. It is also used to treat high grade cancers, which grow and spread quickly, and cancer that comes back after the treatment. However, chemotherapy is not used to treat stage I and II endometrial cancers.

    What are the side effects of chemotherapy?

    The side effects of chemotherapy may vary depending on factors such as the type of chemotherapy, and the dose used. However, some of the common side-effects of chemo treatment may include fatigue, risk of infection, nausea and vomiting, hair loss, loss of appetite, and diarrhea.

    These side effects usually go away after the treatment is finished. Besides, advances in chemotherapy during the last decade include the development of new drugs for the prevention and treatment of side effects, such as nausea and vomiting and reduce the risk of infection.

    Other potential side effects of chemotherapy for uterine cancer include the inability to become pregnant in the future and experiencing early menopause.

    What are the limitations of chemotherapy?

    Primary function of chemo drugs is to kill cancer cells. While these drugs enter the blood and travel through the body killing mostly cancer cells, sometimes these also tend to kill some healthy cells.

    How is chemotherapy given?

    Chemotherapy may be given as an injection, through IV or by mouth (as a pill). These drugs enter the blood and travel through the body killing mostly cancer cells.

    How often do you receive chemotherapy?

    Chemotherapy is usually given in sessions or cycles by injecting the drugs into a vein (intravenously). Chemo sessions depend on the stage and grade of cancer and to the extent it has spread. For uterine cancer, generally up to six sessions, every 3–4 weeks over several months are planned.

    Chemotherapy for uterine cancer is available at all AOI locations. If you’d like to learn more, speak to our representative.

    How can you tell if chemotherapy is working?

    A couple of tests can help your doctor understand if your cancer treatment is working. These include:

    • Blood tests: These tests check for levels of different substances in your blood, like enzymes or proteins that cancer cells or your organs release when the tumor grows.
    • Tumor markers: Tumors release proteins, enzymes, and other chemicals as they grow. Your surgeon can recommend certain tests of your blood, urine, or tissues for these substances to see if your cancer has progressed.
    • X-ray: This imaging test can show where cancer cells are in your body, and whether the cancer is further spreading elsewhere.
    • CT scan: This test uses a powerful x-ray to make detailed pictures. It can show where exactly the cancer is in your body and how well is the treatment working.
    • MRI: MRI uses powerful magnets and radio waves to make pictures of your organs and other structures. It can show where the cancer is in your body.
    • PET, or positron emission tomography: During this test, you get a radioactive substance that is absorbed by the cancer cells in your body. This makes the cancer show up on the images. So, if your treatment is working, your scan will show a fewer highlighted areas.

    Targeted Therapy

    What is hormone therapy?

    Hormone therapy is a cancer treatment that changes the level of certain hormones in your body. Hormones are made by the glands in the body. These are circulated in the bloodstream.

    The hormone treatment either removes hormones or blocks their action to stop cancer cells from growing. It is very different from the hormone therapy that may be used to manage symptoms of menopause.

    How does hormone therapy work against uterine cancer?

    Hormones are chemicals made by glands and circulated in your blood. They control the growth of cancer cells. For instance, hormones estrogen and progesterone can cause cancer cells in the uterus to grow.

    The primary goal of hormone therapy for cancer is to stop cancer cells from getting the hormones they need to grow. The cancer cells may then shrink and die.

    What is hormone therapy treatment for uterine cancer?

    As mentioned above, the hormone therapy uses drugs to keep certain hormones from being made or stop the hormones from helping cancer cells to grow. Such as, in case of endometrial cancer, the hormones affected are estrogen and progesterone.

    So during the treatment you take the medicines that kill or shrink the cancer cells both inside and outside the uterus. These medicines are to be taken by mouth in form of medicine or as a shot.

    Limitations of hormone therapy

    Hormone therapy is effective but is not well suited for all types of uterine cancers. Your gynecologic surgeon is the right person to guide you on this. Also, in some cases, the cancer may respond to the hormone treatment for some time, but its response may not last.

    How is hormone therapy given?

    Most hormone therapy medicines are pills that you can easily take at home. Whereas a few are to be administered as shots or injections.

    Which uterine cancers are treated with hormone therapy?

    Hormone therapy is used to slow the growth of certain types of uterine cancer cells that have receptors to the hormones on them. These tumors are generally endometrial cancer or adenocarcinomas that are grade 1 or 2.

    What are the side effects of hormone therapy?

    Side effects of hormone therapy are alike, but there could be some minor differences with different types of medicines. Also, few of these symptoms are similar to that of menopause, such as: fluid retention, night sweats, vaginal dryness, increase in appetite, insomnia, joint and muscle aches, and weight gain.

    While most side effects of the therapy are manageable, if these drugs are taken for a long time (years), it can weaken bones, leading to osteoporosis.

    At AOI, the best hospital for hormone therapy in India, we’re proud to be at the forefront of uterine cancer treatment. Our team of skilled gynecologic oncologist is constantly looking for ways to more effectively treat uterine cancer, and that includes exploring the potential benefits offered by latest modalities such as hormone therapy and immunotherapy.

    Immunotherapy

    What is Immunotherapy?

    Immunotherapy, also called biologic therapy, is class of treatment that takes advantage of a person’s own immune system to help kill cancer cells. It harnesses certain parts of a patient’s own immune system to fight the disease. These drugs are primarily designed to either strengthen a patient’s immune system or are intended to train the immune system to fight off cancer cells.

    What is immunotherapy treatment for uterine cancer and how does immunotherapy work against uterine cancer?

    A crucial function of the immune system is its ability to keep itself from attacking normal or healthy cells in the body. To do this, it uses “checkpoints” which are molecules on immune cells that need to be turned on (or off) to start an immune response. Cancer cells sometimes use these checkpoints to avoid being attacked by the immune system.

    So, immune checkpoint inhibitors, which are a form of immunotherapy drugs block the cancer proteins from interacting with the immune system, thereby enabling the immune system to continue functioning as intended.

    Unlike other forms of cancer treatment that involve directly attacking the tumor, immunotherapy focuses on strengthening the immune system so that it’s better equipped to fight cancer cells.

    What are the types of immunotherapy?

    For the treatment of uterine cancer, the immune checkpoint inhibitors, which are a type of immunotherapy drugs are commonly used. These drugs have a potential to treat cancers associated with a mismatch repair (MMR) deficiency, a genetic abnormality that prevents cells from fixing mistakes that arise when DNA replicates itself.

    As about one-third of endometrial tumors are MMR-deficient, therefore immune checkpoint inhibitors have potential to serve as an effective treatment method for endometrial cancer.

    Which uterine cancers are treated with immunotherapy?

    Immunotherapy can be used to treat certain types of uterine cancer such as endometrial tumors or the ones that have spread or have recurred.

    What are the side effects of immunotherapy?

    Immunotherapy is generally well tolerated, however, in some patients some side-effects may occur.

    Common side-effects of immunotherapy may include:

    • Fatigue
    • Nausea
    • Weakness
    • Constipation or diarrhoea
    • Flu like symptoms
    • Itching or redness

    Patients may start experiencing these side-effects around two to three months after the therapy starts but early recognition and prompt treatment can help control these side-effects.

    Also, in some rare cases the immune system starts attacking other parts of the body, which can cause serious or even life-threatening problems in the lungs, intestines, liver, hormone-making glands, kidneys, or other organs. So be watchful of any such symptoms and in case of emergency, reach out to your doctor immediately.

    What are the limitations of immunotherapy?

    Immunotherapy is not well-suited to treat all patients, and in some cases, it may only be used when other treatments, such as chemotherapy fail to show any positive results. Also, depending on your stage and grade of cancer, it may be used in combination with other cancer treatments, such as surgery.

    How is immunotherapy given?

    Generally, immunotherapy drugs are given as an intravenous (IV) infusion every 3-4 weeks.

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