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Bile Duct Cancer

Bringing you comprehensive information about different types of Bile Duct Cancer

Bile Duct Cancer

Bringing you comprehensive information about different types of Bile Duct Cancer

AOI > Cancer Types > Bile Duct Cancer > Stages

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    Stages of Bile Duct Cancer

    When and how does my doctor determine the stage of my biliary duct cancer?

    Staging is the process to find out if the cancer has spread within the bile ducts or to the other parts or organs of the body. The stage of your biliary duct cancer is determined from the results of physical exams, imaging tests and biopsies.

    The TNM system, where T refers to the tumor size, N denotes if the lymph nodes in the area of the bile ducts have become cancerous and M suggests if the cancer has spread to other, distant organs in the body, such as your bones, liver, or lungs is a standard system used to stage bile duct cancer.

    The commonly used staging system was developed by the American Joint Committee on Cancer and the International Union Against Cancer.

    Depending on where the cancer starts, bile duct cancers can fall into one of the three different staging systems:

    • Intrahepatic bile duct cancers: The cancer type starts within the liver
    • Perihilar (hilar) bile duct cancers: The cancer type that starts in the hilum; the area just outside the liver
    • Distal bile duct cancers: The cancer type starts farther down the bile duct system

    Nearly all bile duct cancers start in the innermost layer of the wall of the bile duct, called mucosa. Over time, they can grow through the wall toward the outside of the bile duct. So if a tumor grows through the bile duct wall, it can invade nearby blood vessels, organs, and other structures. It might also grow into nearby lymphatic or blood vessels and from there spread to nearby lymph nodes or to other parts of the body.

    How dangerous is biliary duct cancer?

    Even though Cholangiocarcinomas, which are part of the family of tumors known as adenocarcinomas, are rare, they often prove to be fatal.

    What are the stages of biliary duct cancers?

    As mentioned above, based on where the cancer starts, bile duct cancer staging system and its stages may vary as listed below:

    Staging of Intrahepatic Bile Duct Cancer

    The earliest stage Intrahepatic Bile Duct cancers are stage 0. These are also called carcinoma in situ, or CIS. Other stages may range from stages I (1) through IV (4). And as a rule, the lower the number, the less the cancer has spread. A higher number, such as stage IV means the cancer has spread more and therefore, is difficult to treat.

    Staging of Perihilar Bile Duct Cancer

    As with most cancer types, the earliest stage Perihilar Bile Duct cancers are stage 0. These are also called carcinoma in situ (CIS) or high-grade biliary Intraepithelial Neoplasia. Other stages may range from stages I (1) through IV (4). A stage IV bile duct cancer means it has spread more and is at the advanced stage.

    Staging of Distal Bile Duct Cancer

    The earliest stage Distal Bile Duct cancers are stage 0, also called carcinoma in situ (CIS) or high-grade Biliary Intraepithelial Neoplasia. Other stages range from stages I (1) through IV (4). As a rule, the lower the number, the less the cancer has spread.

    Although each person’s cancer experience is unique, cancers with similar stages tend to have a similar outlook and are often treated the same way.

    What is stage 0 biliary duct cancers?

    At this stage the cancer is found only in the innermost layer of the bile duct (mucosa) and has not yet spread to the deeper layers. Also, during this stage, the disease has not invaded lymph nodes or any other distant sites in the body.

    What is stage I biliary duct cancers?

    Stage I (stage 1 bile duct cancer): At this stage, the cancer is contained within the bile duct and has not yet spread to the lymph nodes or other distant sites. However, it may gradually extend into the deeper layers of the bile duct wall.

    What is stage II biliary duct cancers?

    The cancer at this stage has spread through the wall of the bile duct into nearby fat or liver tissue.

    What is stage III biliary duct cancer?

    Stage III (stage 3 bile duct cancer): This stage is divided into two sub-categories:

    • Stage IIIA: The disease during this stage has spread to the main portal vein, the common hepatic artery, duodenum (first part of the small intestine), colon, stomach or abdominal wall, but not beyond. However, the cancer has not spread to the lymph nodes or distant sites.
    • Stage IIIB: Cancer cells during this stage are found in nearby lymph nodes only. They are not yet spread to distant sites or other organs.

    What is stage IV biliary duct cancer?

    Stage IV (stage 4 bile duct cancer): This advanced stage is divided into two subcategories:

    • Stage IVA: The cancer during this stage has spread to the main blood vessel and the lymph nodes but not to the distant sites.
    • Stage IVB: The cancer has either spread to lymph nodes, away from the tumor or it has spread to distant sites.

    What are stage 1 biliary duct cancer symptoms?

    In most cases, bile duct cancer doesn’t usually cause any symptoms until it’s advanced to stages 3 or 4.

    What are end-stage biliary duct cancer symptoms?

    Bile duct cancer doesn’t usually cause any symptoms until the flow of bile from the liver is blocked. In most cases, the condition is at an advanced stage by this time.

    The blockage will cause bile to move back into the blood and body tissue, resulting in symptoms such as:

    • jaundice
    • unintentional weight loss
    • abdominal pain
    • high fever and shivering
    • loss of appetite

    How fast does biliary duct cancer spread?

    Bile duct cancer is a slow-growing cancer and for that reason it is often diagnosed at a later stage. Infact, in most cases, the condition is already at an advanced stage by the time patient experiences any symptoms.

    Advanced cancer can be divided into either of the two types:

    • Locally advanced bile duct cancer that has spread into lymph nodes or organs near the bile duct. A locally advanced cancer might have grown into the liver, small bowel, pancreas or major blood vessels.
    • Bile duct cancer that has spread elsewhere in the body, such as the lungs, bones or lining of the abdomen.
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