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Certain factors increase the risk of small intestine cancer. The risk factors associated with small intestine cancer are:

  • Inherited medical conditions, such as familial adenomatous polyposis, Lynch syndrome, and Peutz-Jeghers syndrome
  • Underlying medical conditions involving the small intestine, such as celiac disease, inflammatory bowel disease, and Crohn's disease
  • The compromised immune system, especially in patients suffering from HIV or who are on immunosuppressant medications as therapy after an organ transplant.