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Radiation Oncology

Using various forms of radiation to safely and effectively treat cancer and other diseases

Radiation Oncology

Using various forms of radiation to safely and effectively treat cancer and other diseases

AOI > Centres of Excellence > Radiation Oncology > Our Facilities

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    Our Facilities

    Medical Linear Accelerator

    American Oncology Institute (AOI) has a well-equipped facility for cancer treatment radiation therapy. We focus on high-tech treatments using high-dose rate that improves accuracy in dose delivery so that patients have to suffer less discomfort during treatments. We are backed-up with various high-end technologies such as external beam radiation therapy, Image-guided Radiation Therapy and Intensity Modulated Radiation Therapy.

    At American Oncology Institute, we contend to improve the patient experience by offering a comprehensive range of medical services and supportive programs.

    Our exclusive range of comprehensive radiation therapy facilities and services:

    EXTERNAL BEAM RADIOTHERAPY

    External beam radiation therapy employs a machine that directs high energy x-rays specifically to the cancer site, avoiding any unnecessary radiation exposure to the unaffected parts of the body. The energy beams are usually generated by a linear accelerator. This type of radiotherapy is useful for providing symptomatic relief in cases of advanced and/or metastasized cancer.

    What is Linear accelerator?

    A linear accelerator (LINAC) is the machine to customize high energy x-rays to conform to a tumor’s shape and aims at destroying the cancer cells while sparing surrounding normal tissue. There are built-in safety features ensuring delivery of radiation dose in precision as prescribed by a medical physicist.

    At American Oncology Institute (AOI) we have linear accelerator with FFF (Flattening filter free) technology which makes it the best type of linear accelerator.

    FFF technology linear accelerator offers many advantages over other types of linear accelerators:

    • Improved dose calculation – increased dose rate with reduced head scattering and leakage radiation
    • Faster and more accurate dose delivery to normal tissues
    • Reduced dose requirement
    • Less radiation exposure to patient

    What are the types of external beam radiation therapy?

    External beam radiation therapy is of different types such as:

    • Three-dimensional conformal radiation therapy (3D CRT) – Three-dimensional conformal radiation therapy (3D CRT) – 3D CRT is one of the common types of external beam radiation therapy. The images are used from MRI, CT and PET scans and are helpful in precisely planning the treatment area. Later, these images are analyzed by a computer and the radiation beam is designed that conforms to the shape of the tumor from many directions. The exact and precise shape of the tumor is important to deliver high doses of radiation to the tumor tissue while sparing the normal tissue. 3D CRT is used to treat cancerous and noncancerous tumors within the body.
      At American Oncology Institute (AOI) we have External beam with 3D-CRT which confers the advantage of better precision in radiation dose delivery the target organ or organs and hence less radiation exposure to the patient.
    • Intensity-modulated radiation therapy (IMRT) – Intensity-modulated radiation therapy (IMRT) is a high-precision radiotherapy that uses computer-controlled linear accelerators. IMRT allows precise radiation dose the tumor by modulating the intensity of the photon and proton beams of radiation, in multiple small volumes, to match the 3D shape of the tumor. With IMRT, dose painting technique is possible i.e., selective delivery of high dose radiation to the high risk areas and less dose to the low risk areas into the tumor mass.
      The dose painting technique in IMRT offers advantages such as:

      • More precise radiation delivery to affected area.
      • Minimized exposure to adjacent normal tissue.

      Due to its higher degree of accuracy, IMRT may be a treatment option for patients who have reached the maximum allowable dose of conventional radiation therapy and have a recurrent tumor in the treated area. The radiation oncologist might call the patient for multiple sessions depending on the cancer type, size and its location.

      IMRT is used for the treatment of many solid cancers such as head and neck cancer, brain cancer, prostate cancer, lung cancer, uterine cancer, gastrointestinal cancers, breast cancer and others specifically due to the vicinity of these tumors to the critical organs and tissues in the body.

      American Oncology Institute (AOI) offers better cancer care facilities with such advanced technologies like IMRT in radiotherapy.

    • Rapid Arc radiation therapy / Volumetric Arc Therapy (VMAT) : It’s a type of IMRT technique. The machine rotates around the patient while administering radiation in an arc shape, along with the changing intensity of the radiation beam as it moves around the body.
      Advantages of Rapid arc/VMAT technique:

      • Less time consuming (usually a few minutes) and hence shortened treatment time
      • Improved tumor targeting
      • Accurate and lower overall dosing
      • Less side effects thus more tolerable to patients

      AOI radiotherapy possess advanced radiation technologies and contributes to better cancer treatment outcomes.

    What are the benefits with IMRT technique or how is IMRT better than conventional radiotherapy?

    One of the major advantages of IMRT over conventional radiotherapy techniques, is that the ratio of normal tissue dose to tumor dose is reduced to a minimum, hence higher and more effective radiation doses can be safely administered to tumors with fewer adverse effects. IMRT also has the potential to reduce treatment toxicity, even when doses are not increased.

    • Image-guided radiation therapy (IGRT) – Image-guided radiation therapy (IGRT) is the radiotherapy modality that uses imaging scans during radiation therapy sessions and improves the precision and accuracy in treatment delivery.
      IGRT is one of the suitable radiation delivery methods especially in case of tumors located in movable areas of the body, such as the lungs, heart. In these cases, organ filling or movements while breathing imaging may change between treatments due to the rhythmic movements and thereby in order to account for these changes, IGRT uses repeated imaging scans. The images are compared with reference images that allows more precise dose adjustment and radiation beam alignment towards the target tumor tissue. These adjustments make the treatment more accurate and help spare the surrounding normal tissue. IGRT procedures may use ultrasound, MRI, CT scan, 3-D body surface mapping, electromagnetic transponders or colored ink tattoos on the skin as markers.

    INTERNAL BEAM RADIOTHERAPY OR BRACHYTHERAPY OR INTRACAVITARY RADIATION THERAPY

    Brachytherapy is a type of internal radiation therapy which places radioactive tracers or sources in the form of pellets, seeds, capsules, wires, needles or tubes, directly inside or near the tumor location in the body and destroys cancer cells and helps in shrinkage of tumor mass.

    What are the advantages of Brachytherapy or Internal beam radiation therapy compared to external beam radiotherapy?

    • Higher dose of radiation can be delivered in a smaller area which might not be done with external radiation treatment.
    • Due to the placement of tracers just near or inside the tumor, there is minimal harm to the nearby normal tissue. This makes it more precise for radiation dose delivery.
    • Also, the radiation oncologist can use a higher total dose of radiation to treat a smaller area within less time than external beam radiation therapy.
    • Decreases risk of radiation-induced second malignancies, which is a serious concern in children.

    Brachytherapy for cancer treatment provides a local radiation treatment since it treats only a specific part of body. Brachytherapy is often used to treat cancers of the breast, head and neck, cervix, prostate, eye, skin, gall bladder, etc. In case of pediatric cancers, brachytherapy is used for rare cancers like rhabdomyosarcoma.

    What are the types of brachytherapy?

    • Based on the duration of radioactive tracer placement inside body, brachytherapy can be temporary or permanent:
      • Temporary brachytherapy – Temporary brachytherapy uses implants such as hollow tubes (catheters), needles, balloons that are placed or implanted near or into the tumor for a specific period and then later removed after the treatment is over. It can be either given at a low-dose rate (LDR) or high-dose rate (HDR).
        Advantages of HDR brachytherapy:

        • High doses in short time and directly into the tumor mass
        • Less painful to the patient
        • Less time consuming (usually day-care admission)
        • Quick recovery and thus patient can be back to work soon
      • Permanent brachytherapy or seed implantation – The radioactive seeds measuring about the size of a grain of rice are placed in or near the tumor permanently. The seeds lose their radioactivity gradually in certain months.
    • Based on the placement of the radiation dose delivery devices or applicators in the patient’s body:
      • Intraluminal – Applicators placement inside tubular organs.
        • Uses: cancer of esophagus, bronchus, endometrial cancer
      • Intracavitary – Applicators placement inside hollow organs.
        • Uses: Cervical cancer
      • Interstitial – Certain needles/catheters are placed through the tumor.
        • Uses: prostate cancer, breast cancer, liver cancer, buccal mucosa and lip cancer

    What is Martinez Universal Perineal Interstitial Template (MUPID)?

    Martinez Universal Perineal Interstitial Template (MUPIT) is named after Martinez, as one of the devices in brachytherapy. It is an interstitial template with insertion needles to be placed at perineal region, especially used in treatment of gynecological cancers such as cervical cancer, vaginal cancer, perineum, prostate cancer in men, etc.

    Martinez Universal Perineal Interstitial Template (MUPID) is used for which type of cancer?

    Martinez Universal Perineal Interstitial Template (MUPID) is used especially in cancer of prostate, cervix, vagina, perineum and anorectal. It helps in a better and controlled placement as well as delivery of the radioactive tracer substance into the tumor region and provides precise exposure.

    What are the advantages of using MUPID in gynecological cancers treatment?

    • Controlled placement as well as delivery of the radioactive tracer substance allowing precision in the treatment of tumor area.
    • Improved local control
    • Reduced toxicity
    • Improved overall survival for women

    At American Oncology Institute (AOI), we offer better diagnosis and treatment with our advanced techniques and machines for various types of cancers including gynaecological malignancies. At AOI, we have advanced facilities for treatment of gynaecological malignancies such as Mupid perineal template which is one of the most flexible form of gynecologic brachytherapy available at very few cancer care centers. With AOI, you can feel assured for a standard and advanced cancer treatment.

    STEREOTACTIC BODY RADIATION THERAPY (SBRT) AND STEREOTACTIC RADIOSURGERY (SRS)

    Stereotactic body radiation therapy (SBRT), or stereotactic radiosurgery (SRS), is a form of radiation therapy delivers higher dose of radiation than conventional to the tumor in a very precise manner. The term ‘radiosurgery’ despite the word ‘surgery’ in it, does not involve any such surgery in the procedure, rather it is a technique in radiation therapy.

    When this technique is used for treatment of brain tumors and functional abnormalities, it is called as stereotactic radiosurgery (SRS) and when used to treat body tumors, it is called stereotactic body radiotherapy (SBRT). Both these procedures are usually OPD-basis (out-patient department) procedures.

    What are the advantages of stereotactic body radiation therapy (SBRT) and stereotactic radiosurgery (SRS) over conventional radiotherapy?

    • The radiation dose delivered to the tumor in stereotactic body radiation therapy (SBRT), is higher and very precise compared to the conventional radiotherapy.
    • Stereotactic radiation involves fewer treatments (called “fractions”), mostly single fraction and reserved for brain lesion treatments depending on the diagnosis than conventional radiotherapy techniques.
    • SRS and SBRT both are a patient-friendly treatment option who reside in distant and interior village locations from treatment centres, contrast to conventional radiotherapy.
    • SRS and SBRT also offer a treatment option that is non-invasive and can be completed in the outpatient setting, thus potentially freeing up valuable inpatient hospital resources as well as allowing patients to resume their normal daily activity as quickly as possible.
    • Both from payer and societal perspectives, the clinical and cost-effectiveness of SRS and SBRT have been demonstrated to reduce health system utilization (medication, retreatment, etc.) and minimize indirect costs, thus saving payers additional financial resources, and reducing the strain on the workforce.
    • SBRT and SRS deliver precisely-targeted radiation in fewer high-dose treatments than traditional therapy, which helps preserve healthy tissue.
      Stereotactic radiation achieves same biological effect even in fewer fractions, higher dose than conventional radiation therapy.
    • Stereotactic radiation helps the radiation oncologist to focus radiation very precisely to the target lesion’s/ tumor’s location.

    How are stereotactic body radiation therapy (SBRT) and stereotactic radiosurgery (SRS) different from conventional radiotherapy?

    • The mechanism of destruction of cancer cells is different in stereotactic and conventional radiation. Stereotactic radiation kills cancer cells by DNA and blood vessel damage whereas conventional radiation therapy prevents the replication and multiplication of cancer cells.
    • SBRT can be used only in selected cases because it delivers high doses of radiation; also, it might not be safe at tumor/lesion sites in vicinity of sensitive structures unlike the conventional radiotherapy.

    What are the various treatment modalities or machines employed to deliver stereotactic radiation?

    Conventional radiation therapy uses Linear accelerator machine whereas stereotactic radiotherapy employs three types of modalities deliver radiation namely – X knife, Gamma Knife, CyberKnife, and a highly advanced Linear Accelerator.

    • Gamma knife
    • Cyber knife
    • Advanced Linear Accelerator Linac-based SBRT/ SRS with FFF technique

    At American Oncology Institute, we offer stereotactic radiation therapy and radiosurgery with FFF technique which is exclusively used for the treatment of brain tumors or abnormalities.

    GammaKnife stereotactic radiosurgery

    The GammaKnife stereotactic radiosurgery is useful in cases of brain tumor and other abnormalities in brain due to its high precision of radiation delivery. With this technique, not even only brain tumors but certain malformations in brain are treated using Magnetic Resonance Imaging and stereotactic guides which further aid in target volume localization. The patient’s head is stabilized using a frame, later followed by MRI scan which helps in better visualization and serves as a stable reference point for the tumor location. Following this treatment, the benign tumors usually shrink over a period taking few months to years gradually with time. The tumor shrinkage is more rapid and evident in case of malignant and metastatic tumors, as rapid as in a couple of months.

    TOTAL BODY IRRADIATION (TBI)

    Radiation therapy when given to the whole body, is called total body irradiation or TBI. Total Body Irradiation (TBI) is one main component in the interdisciplinary treatment of widely disseminated malignancies predominantly of haematopoietic diseases. Combined with intensive chemotherapy, TBI enables myeloablative high dose therapy and immuno-ablative conditioning treatment prior to subsequent transplantation of haematopoietic stem cells: bone marrow stem cells or peripheral blood progenitor stem cells.

    What are the uses of TBI?

    Total Body Irradiation (TBI) is used for the treatment of Leukaemia in adults and childhood such as Acute lymphoblastic leukaemia (ALL), Acute myeloid leukaemia (AML), Chronic myeloid leukaemia (CML), Myelodysplastic syndrome (MDS).

    DIBH TECHNIQUE

    What are the advantages of DIBH technique?

    In radiation therapy, precise delivery of radiation is always important to prevent other unaffected regions near the tumour. Among many ways to minimise the radiation dose to the heart, DIBH is the one that is suitable for some patients. It minimizes the radiation dose exposure while moving it away from lungs with high precision.

    What is DIBH technique?

    Deep inspiration breath hold (DIBH) is a radiation therapy technique where patients are asked to take a deep breath and hold it while they are being administered radiation therapy. This actually expands the lungs to almost full and moves the heart away.

    DIBH is specifically useful in cases where radiation therapy has to be given in the chest region minimizing radiation dose to the heart.

    What are the uses of DIBH in radiation therapy or radiotherapy?

    DIBH in radiation therapy is useful for:

    • Left-sided breast cancer
    • Lymphoma in the chest region
    • Other tumours in the chest or upper abdomen region

    At American Oncology Institute (AOI), we have the facility of DIBH technique for left sided breast cancer, where we can deliver a high precision radiotherapy targeting the tumour with least possible dose to the heart and lungs.

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