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Uterine Cancer

Bringing you comprehensive information about different types of Uterine Cancer

Uterine Cancer

Bringing you comprehensive information about different types of Uterine Cancer

AOI > Cancer Types > Uterine Cancer > Stages

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    When and how does my doctor determine the stage of my uterine cancer?

    Surgeons examine tissue from the uterus under a microscope to identify cancer cells. This helps them to stage and understand if the cancer cells look similar to healthy cells and are slow-growing, low-grade tumors or if they are high-grade tumors that may spread quickly.

    Other tests such as pelvic exam, pap test, x-ray, CT scan, MRI and/or PET scan may also help with staging.

    Oncologists use one of two systems for staging cancer:

    The International Federation of Gynecology and Obstetrics, also called as the FIGO system and the TNM (Tumor, Node, Metastasis) staging system of the American Joint Committee on Cancer (AJCC). They classify cancer based on:

    • The extent of the tumor
    • Whether the cancer has spread to nearby lymph nodes
    • Whether the cancer has spread to other sites in the body

    While both systems helps in staging the cancer but unlike the TNM system, the FIGO system does not include stage 0. Basically, stage 0 is also known as carcinoma in-situ. During this stage, cancer cells are only found in the surface layer of cells of the endometrium, without growing into the layers of cells below. Also, the cancer at this pre-cancerous stage has not yet spread to nearby lymph nodes or distant sites.

    What are the stages of uterine cancer?

    The stages of cancer are similar for both types of uterine cancer — endometrial cancer and uterine sarcoma.

    Here’s what the stages mean:

    • Stage 0: A very early stage of cancer. Found in one layer of cells and confined to one place only.
    • Stage I: Cancer at this stage is found in the uterus only. It is not yet spread to other parts of the body.
    • Stage II: In case of endometrial cancer, the tumor has spread into the connective tissue of the cervix, which lies at the base of the uterus.
      While in case of the uterine sarcoma, the cancer is growing outside the uterus but is confined to the pelvis and has not spread to lymph nodes.
    • Stage III: For endometrial cancer, the tumor has spread beyond the uterus and cervix but is still contained within the pelvis. Substages indicate where the cancer has spread and also if it has progressed to lymph node yet.
      The progression for stage III uterine sarcoma is as follows:
      IIIA: Cancer has spread to abdominal tissue and in one place only
      IIIB: Cancer is growing into two or more places in the abdomen
      IIIC: Cancer may have grown into the pelvis or abdomen and has spread to nearby lymph nodes as well.
    • Stage IV: In case of endometrial cancer:
      IVA: The cancer has spread to the rectum or bladder.
      IVB: Cancer has entered the lymph nodes and/or has spread to distant organs such as the bones or lungs as well.
      Similarly, Stage IV uterine sarcoma means:
      IVA: Cancer has spread to the bladder or rectum
      IVB: Cancer has spread to organs such lungs or distant lymph nodes.

    What is stage I uterine cancer?

    Stage I (stage 1 uterine cancer): The cancer at this stage is only found in the body of the uterus. There’s a possibility that it may also be growing into the glands of the cervix. But it is not growing into the supporting connective tissue of the cervix. Also, the cancer has not spread to lymph nodes or distant sites.

    Stage I has two subcategories:

    • Stage IA: In this earliest form of stage I, the cancer is in the endometrium from where it may have invaded the underlying muscle layer of the uterus.
      It has not yet spread to lymph nodes or other distant sites.
    • Stage IB: The cancer has grown from the endometrium into the myometrium but has not spread beyond the body of the uterus.

    What is stage II uterine cancer?

    Stage II (stage 2 uterine cancer): The cancer has spread from the body of the uterus and is growing into the supporting connective tissue of the cervix.

    The cancer has not spread outside of the uterus or to lymph nodes or distant sites.

     

    What is stage III uterine cancer?

    Stage III (stage 3 uterine cancer): The cancer has either spread outside of the uterus or into nearby tissues in the pelvic area. This stage has four subcategories:

    • Stage IIIA: The cancer has spread to the outer surface of the uterus and/or to the fallopian tubes or ovaries but it has not yet spread to lymph nodes or distant sites.
    • Stage IIIB: The cancer during this stage has spread to the vagina or to the tissues around the uterus but has not yet spread to lymph nodes or distant sites.
    • Stage IIIC1: The cancer is growing in the body of the uterus. It may have spread to some nearby tissues, but not inside of the bladder or rectum.
      The cancer has spread to pelvic lymph nodes but not to lymph nodes around the aorta or distant sites.
    • Stage IIIC2: The cancer is growing in the body of the uterus. It may have spread to some nearby tissues, but not inside of the bladder or rectum.
      The cancer has spread to lymph nodes around the aorta (peri-aortic lymph nodes) but not to distant sites.

    What is stage IV uterine cancer?

    Stage IV (stage 4 uterine cancer): The cancer has spread to the inner surface of the urinary bladder or the rectum, to lymph nodes in the groin, and/or to distant organs, such as the bones, omentum or lungs.

    Stage IV uterine cancer has two subcategories:

    • Stage IVA: The cancer has spread to the inner lining of the rectum or urinary bladder. It may or may not have spread to nearby lymph nodes but has not spread to the distant sites.
    • Stage IVB: The cancer has spread to the distant lymph nodes, the upper abdomen, the omentum, or to organs away from the uterus, such as the bones, omentum or lungs.

    When and how does my doctor determine the stage of my uterine cancer?

    Once your cancer has been diagnosed, your surgeon works to determine the stage of your cancer through various diagnostic tests that includes a chest x-ray, a CT scan, PET scan and blood tests.

    Oncologists at American Oncology Institute are the best cancer surgeons for uterine cancer in India who have pioneered the approach for determining where gynecologic cancers are likely to spread first, allowing them to remove a limited number of lymph nodes and reduce complications of surgery.

    What are the stages of uterine cancer?
    The International Federation of Gynecology and Obstetrics classifies endometrial cancer into four stages:

    • Stage I: Cancer that is confined to the uterus
    • Stage II: Cancer spread to the cervix
    • Stage III: Cancer spread to the vagina, ovaries, and/or lymph nodes
    • Stage IV: Cancer spread to the urinary bladder, rectum, or organs located far from the uterus, such as the lungs or bones.

    Nearly 70% women are diagnosed with the early stage uterine cancer, when the cancer is still within the uterus. Another 20% are diagnosed when the cancer has metastasized or spread to nearby organs and lymph nodes, and remaining 10% are diagnosed when it has spread to distant parts of the body.

    Is stage 4 uterine cancer curable?
    Stage 4 uterine cancer is the advance stage when the cancer has spread to other parts of the body. In most cases, however, stage IV cancer is not curable, but that doesn’t mean that there is no effective treatment.

    Is stage 4 uterine cancer terminal?
    In most cases of stage IV endometrial cancer, the cancer has spread too far for it to be removed completely with surgery. But despite that to control symptoms such as excessive bleeding, a hysterectomy and removal of both fallopian tubes and ovaries may still be done. Even radiation therapy may be used in some cases.

    What is the most aggressive uterine cancer?
    There are different types of uterine cancer, some more aggressive than others. While the majority of cancers arising in the womb are slow growing, others are more aggressive which means that it may grow or spread quickly into other organs, or recur quickly.

    Uterine sarcomas, which develop in the muscle tissue of the uterus (the myometrium) are the most aggressive form of uterine cancer.

    Even mixed tumors (carcinosarcomas) that arise from both the muscle tissue and the endometrium are found to be aggressive.

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